{"id":2,"date":"2015-03-09T07:11:06","date_gmt":"2015-03-09T07:11:06","guid":{"rendered":"http:\/\/www.hosp.tohoku.ac.jp\/hct\/?page_id=2"},"modified":"2024-03-19T10:02:12","modified_gmt":"2024-03-19T01:02:12","slug":"about","status":"publish","type":"page","link":"https:\/\/www.hosp.tohoku.ac.jp\/hct\/about\/","title":{"rendered":"\u9020\u8840\u5e79\u7d30\u80de\u79fb\u690d\u3068\u306f"},"content":{"rendered":"

\u79fb\u690d\u306e\u7a2e\u985e\u3068\u7279\u5fb4<\/h2>\n

\u3000\u9020\u8840\u5e79\u7d30\u80de\u79fb\u690d\u306b\u306f\u5927\u304d\u304f\u5206\u3051\u3066\u3001\u60a3\u8005\u3055\u3093\u81ea\u8eab\u306e\u9020\u8840\u5e79\u7d30\u80de\u3092\u4f7f\u7528\u3059\u308b\u81ea\u5bb6\u9020\u8840\u5e79\u7d30\u80de\u79fb\u690d\u3068\u5065\u5e38\u30c9\u30ca\u30fc\u304b\u3089\u9020\u8840\u5e79\u7d30\u80de\u306e\u63d0\u4f9b\u3092\u53d7\u3051\u308b\u540c\u7a2e\u9020\u8840\u5e79\u7d30\u80de\u79fb\u690d\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n

\n

1. \u81ea\u5bb6\u9020\u8840\u5e79\u7d30\u80de\u79fb\u690d\uff08\u81ea\u5bb6\u79fb\u690d\uff09<\/h3>\n<\/div>\n

\n\u6982\u8981<\/strong>
\n\u3000\u60a3\u8005\u3055\u3093\u81ea\u8eab\u306e\u9020\u8840\u5e79\u7d30\u80de\u3092\u3042\u3089\u304b\u3058\u3081\u63a1\u53d6\u30fb\u4fdd\u5b58\u3057\u3066\u304a\u304d\u3001\u5927\u91cf\u5316\u5b66\u7642\u6cd5\u65bd\u884c\u5f8c\u306b\u81ea\u8eab\u306e\u9020\u8840\u5e79\u7d30\u80de\u3092\u8f38\u6ce8\u3059\u308b\uff08\u3082\u3069\u3059\uff09\u6cbb\u7642\u6cd5\u3067\u3059\u3002\u9020\u8840\u5e79\u7d30\u80de\u3092\u5927\u91cf\u306e\u6297\u304c\u3093\u5264\u306b\u66b4\u9732\u3055\u305b\u306a\u3044\u3053\u3068\u3067\u3001\u901a\u5e38\u3088\u308a\u3082\u5927\u91cf\u306e\u5316\u5b66\u7642\u6cd5\u306e\u6295\u4e0e\u3092\u53ef\u80fd\u306b\u3057\u307e\u3059\u3002\n<\/p>\n

\n\u4e3b\u306a\u5bfe\u8c61\u75be\u60a3<\/strong>
\n\u300065\u6b73\u672a\u6e80\u306e\u591a\u767a\u6027\u9aa8\u9ac4\u816b\u3067\u306f\u6a19\u6e96\u7684\u306b\u65bd\u884c\u3055\u308c\u307e\u3059\u3002\u307e\u305f\u3001\u3073\u307e\u3093\u5927\u7d30\u80de\u578bB\u7d30\u80de\u30ea\u30f3\u30d1\u816b\u306e\u518d\u767a\u4f8b\u3067\u5316\u5b66\u7642\u6cd5\u3078\u306e\u611f\u53d7\u6027\u304c\u3042\u308b\u5834\u5408\u306b\u3082\u65bd\u884c\u3055\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u305d\u306e\u4ed6\u3001\u4e00\u90e8\u306e\u518d\u767a\u9ad8\u30ea\u30b9\u30af\u306e\u60aa\u6027\u30ea\u30f3\u30d1\u816b\u3067\u306f\u7b2c\u4e00\u5bdb\u89e3\u671f\u3067\u306e\u81ea\u5bb6\u79fb\u690d\u304c\u65bd\u884c\u3055\u308c\u308b\u3053\u3068\u3082\u3042\u308a\u307e\u3059\uff08\u81e8\u5e8a\u8a66\u9a13\u3067\u306e\u691c\u8a0e\u304c\u591a\u3044\uff09\u3002\n<\/p>\n

\n\u81ea\u5bb6\u9020\u8840\u5e79\u7d30\u80de\u306e\u63a1\u53d6<\/strong>
\n\u3000\u9aa8\u9ac4\u3067\u306f\u306a\u304f\u3001\u672b\u68a2\u8840\u5e79\u7d30\u80de\u3092\u4f7f\u7528\u3059\u308b\u3053\u3068\u304c\u4e00\u822c\u7684\u3067\u3059\u3002\u5316\u5b66\u7642\u6cd5\u5f8c\u306bG-CSF\uff08\u9846\u7c92\u7403\u30b3\u30ed\u30cb\u30fc\u523a\u6fc0\u56e0\u5b50\uff09\u3092\u6295\u4e0e\u3059\u308b\u3068\u3001\u767d\u8840\u7403\u6570\u304c\u5897\u52a0\u3059\u308b\u6642\u671f\u306b\u9aa8\u9ac4\u304b\u3089\u672b\u68a2\u8840\u3078\u9020\u8840\u5e79\u7d30\u80de\u304c\u8a98\u5c0e\u3055\u308c\u307e\u3059\u3002\u9020\u8840\u5e79\u7d30\u80de\u306f\u300cCD34\u300d\u3068\u3044\u3046\u86cb\u767d\u8cea\u304c\u967d\u6027\u3068\u306a\u308a\u307e\u3059\u3002\u6771\u5317\u5927\u5b66\u75c5\u9662\u3067\u306f\u3001\u671d\u306e\u63a1\u8840\u3067\u5fc5\u8981\u306aCD34\u967d\u6027\u7d30\u80de\u6570\u304c\u78ba\u8a8d\u3067\u304d\u305f\u65e5\u306b\u8840\u6db2\u6210\u5206\u63a1\u53d6\u88c5\u7f6e\u3092\u7528\u3044\u3066\u3001\u9020\u8840\u5e79\u7d30\u80de\u3092\u63a1\u53d6\u3057\u3066\u3044\u307e\u3059\u3002\u63a1\u53d6\u5f8c\u306f\u6db2\u4f53\u7a92\u7d20\u3084-80\u2103\u306e\u51b7\u51cd\u5eab\uff08\u65e9\u671f\u306b\u4f7f\u7528\u3059\u308b\u5834\u5408\uff09\u306b\u4fdd\u5b58\u3057\u3001\u79fb\u690d\u6642\u307e\u3067\u4fdd\u7ba1\u3057\u307e\u3059\u3002\n<\/p>\n

\n\u81ea\u5bb6\u79fb\u690d\u306e\u65b9\u6cd5<\/strong>
\n\u3000\u79fb\u690d\u524d\u306b\u306f\u524d\u51e6\u7f6e\u3068\u3088\u3070\u308c\u308b\u5927\u91cf\u5316\u5b66\u7642\u6cd5\u3092\u884c\u3044\u307e\u3059\u3002\u591a\u767a\u6027\u9aa8\u9ac4\u816b\u306b\u5bfe\u3057\u3066\u306f\u5927\u91cf\u30e1\u30eb\u30d5\u30a1\u30e9\u30f3(MEL)\u3001\u60aa\u6027\u30ea\u30f3\u30d1\u816b\u306b\u306fM-BEAM\uff08MCNU, ETP, CA, MEL\uff09\u306a\u3069\u306e\u30ec\u30b8\u30e1\u30f3\u304c\u7528\u3044\u3089\u308c\u308b\u3053\u3068\u304c\u591a\u3044\u3067\u3059\u3002\u60a3\u8005\u3055\u3093\u306e\u72b6\u614b\u3001\u65bd\u8a2d\u306e\u65b9\u91dd\u3001\u81e8\u5e8a\u8a66\u9a13\u306b\u3088\u3063\u3066\u3001\u7570\u306a\u308b\u524d\u51e6\u7f6e\u304c\u7528\u3044\u3089\u308c\u308b\u5834\u5408\u3082\u3042\u308a\u307e\u3059\u3002\u597d\u4e2d\u7403\u304c3\u56de\u9023\u7d9a\u3057\u3066500\/\u03bcl\u3092\u8d85\u3048\u308b\u3053\u3068\u3092\u751f\u7740\u3068\u547c\u3073\u307e\u3059\u304c\u3001\u81ea\u5bb6\u672b\u68a2\u8840\u5e79\u7d30\u80de\u79fb\u690d\u5f8c\u306f2\u9031\u9593\u4ee5\u5185\u306b\u751f\u7740\u3059\u308b\u3053\u3068\u304c\u307b\u3068\u3093\u3069\u3067\u3059\u3002\n<\/p>\n

\n\u81ea\u5bb6\u79fb\u690d\u306e\u554f\u984c\u70b9<\/strong>
\n\u3000\u60a3\u8005\u81ea\u8eab\u306e\u7d30\u80de\u3092\u8f38\u6ce8\u3059\u308b\uff08\u623b\u3059\uff09\u3053\u3068\u304b\u3089\u3001\u79fb\u690d\u3057\u305f\u7d30\u80de\u304c\u60a3\u8005\u3055\u3093\u306e\u4f53\u3092\u514d\u75ab\u53cd\u5fdc\u306b\u3088\u3063\u3066\u653b\u6483\u3059\u308bGraft-versus-host Disease (GVHD)\u306e\u30ea\u30b9\u30af\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u4e00\u65b9\u3067\u304c\u3093\u7d30\u80de\u306b\u5bfe\u3059\u308b\u653b\u6483\uff08Graft-versus-leukemia\/lymphoma\u52b9\u679c\uff09\u3082\u671f\u5f85\u3067\u304d\u307e\u305b\u3093\u3002\u81ea\u5bb6\u79fb\u690d\u306f\u3001\u3042\u304f\u307e\u3067\u79fb\u690d\u524d\u51e6\u7f6e\u306b\u7528\u3044\u308b\u5927\u91cf\u5316\u5b66\u7642\u6cd5\u306e\u52b9\u679c\u306b\u4f9d\u5b58\u3057\u305f\u6cbb\u7642\u6cd5\u3067\u3059\u3002\u307e\u305f\u3001\u5316\u5b66\u7642\u6cd5\u5f8c\u306b\u9020\u8840\u5e79\u7d30\u80de\u3092\u63a1\u53d6\u3057\u3066\u3082\u816b\u760d\u7d30\u80de\u304c\u79fb\u690d\u7247\u306b\u6df7\u5165\u3059\u308b\u30ea\u30b9\u30af\u3092\u30bc\u30ed\u306b\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u3002\n<\/p>\n

\n

2. \u540c\u7a2e\u9020\u8840\u5e79\u7d30\u80de\u79fb\u690d\uff08\u540c\u7a2e\u79fb\u690d\uff09<\/h3>\n<\/div>\n

\n\u6982\u8981<\/strong>
\n\u3000\u5927\u91cf\u5316\u5b66\u7642\u6cd5\u3084\u5168\u8eab\u653e\u5c04\u7dda\u7167\u5c04\u306a\u3069\u3092\u7d44\u307f\u5408\u308f\u305b\u305f\u79fb\u690d\u524d\u51e6\u7f6e\u306e\u5f8c\u306b\u5065\u5e38\u30c9\u30ca\u30fc\u7531\u6765\u306e\u9020\u8840\u5e79\u7d30\u80de\u3092\u8f38\u6ce8\uff08\u79fb\u690d\uff09\u3057\u3001\u60a3\u8005\u3055\u3093\u306e\u9020\u8840\u304a\u3088\u3073\u514d\u75ab\u7cfb\u3092\u30c9\u30ca\u30fc\u7531\u6765\u306e\u9020\u8840\u30fb\u514d\u75ab\u7cfb\u306b\u7f6e\u304d\u63db\u3048\u308b\u6cbb\u7642\u6cd5\u3067\u3059\u3002\u4e00\u5375\u6027\u53cc\u751f\u5150\uff08\u540c\u7cfb\u79fb\u690d\uff09\u4ee5\u5916\u306e\u30c9\u30ca\u30fc\u304b\u3089\u79fb\u690d\u3092\u884c\u3046\u5834\u5408\u306b\u306fGVHD\uff08\u30c9\u30ca\u30fc\u306e\u514d\u75ab\u7d30\u80de\u304c\u60a3\u8005\u3055\u3093\u306e\u4f53\u3092\u7570\u7269\u3068\u8a8d\u8b58\u3057\u3066\u969c\u5bb3\u3059\u308b\u53cd\u5fdc\uff09\u306e\u4e88\u9632\u304c\u5fc5\u9808\u3068\u306a\u308a\u307e\u3059\u3002\u30c9\u30ca\u30fc\u306f\u8840\u7e01\uff08\u540c\u80de\u3001\u975e\u540c\u80de\uff1d\u89aa\u5b50\u3084\u5f93\u59b9\uff09\u3001\u975e\u8840\u7e01\u306b\u5206\u304b\u308c\u3001\u7528\u3044\u308b\u9020\u8840\u5e79\u7d30\u80de\u6e90\u306b\u306f\u9aa8\u9ac4\u3001\u672b\u68a2\u8840\u5e79\u7d30\u80de\u3001\u81cd\u5e2f\u8840\u306e3\u7a2e\u985e\u304c\u3042\u308a\u307e\u3059\u3002\u307e\u305f\u3001\u30c9\u30ca\u30fc\u3068\u60a3\u8005\u3055\u3093\u306eHLA\uff08\u767d\u8840\u7403\u306e\u578b\uff09\u306e\u4e00\u81f4\u5ea6\u306b\u3088\u3063\u3066\u3082\u79fb\u690d\u306e\u65b9\u6cd5\u3084\u6210\u7e3e\u304c\u7570\u306a\u308a\u307e\u3059\u3002\n<\/p>\n

\n\u4e3b\u306a\u5bfe\u8c61\u75be\u60a3<\/strong>
\n\u3000\u5316\u5b66\u7642\u6cd5\u306e\u307f\u3067\u306f\u6cbb\u7652\u3092\u671f\u5f85\u3067\u304d\u306a\u3044\u304b\u3001\u9ad8\u3044\u78ba\u7387\u3067\u518d\u767a\u3059\u308b\u3068\u4e88\u60f3\u3055\u308c\u308b\u6025\u6027\u767d\u8840\u75c5\u3084\u60aa\u6027\u30ea\u30f3\u30d1\u816b\u3001\u8f38\u8840\u4f9d\u5b58\u3084\u9ad8\u30ea\u30b9\u30af\u306e\u9aa8\u9ac4\u7570\u5f62\u6210\u75c7\u5019\u7fa4\u3001\u514d\u75ab\u6291\u5236\u7642\u6cd5\u304c\u7121\u52b9\u306a\u518d\u751f\u4e0d\u826f\u6027\u8ca7\u8840\u300140\u6b73\u672a\u6e80\u3067HLA\u4e00\u81f4\u540c\u80de\u30c9\u30ca\u30fc\u3092\u6709\u3059\u308b\u518d\u751f\u4e0d\u826f\u6027\u8ca7\u8840\u3001\u30c1\u30ed\u30b7\u30f3\u30ad\u30ca\u30fc\u30bc\u963b\u5bb3\u85ac\u3067\u826f\u597d\u306a\u53cd\u5fdc\u304c\u5f97\u3089\u308c\u306a\u3044\u6162\u6027\u9aa8\u9ac4\u6027\u767d\u8840\u75c5\u3001\u6162\u6027\u9aa8\u9ac4\u6027\u767d\u8840\u75c5\u306e\u6025\u6027\u671f\u3001\u306a\u3069\u304c\u4ee3\u8868\u7684\u306a\u5bfe\u8c61\u75be\u60a3\u3068\u306a\u308a\u307e\u3059\u3002\u307e\u305f\u6a19\u6e96\u30ea\u30b9\u30af\u306e\u6025\u6027\u767d\u8840\u75c5\u3067\u3082\u82e5\u5e74\u60a3\u8005\u3067HLA\u4e00\u81f4\u540c\u80de\u30c9\u30ca\u30fc\u304c\u3044\u308b\u5834\u5408\u306b\u306f\u7b2c\u4e00\u5bdb\u89e3\u671f\u3067\u79fb\u690d\u304c\u691c\u8a0e\u3055\u308c\u3066\u3044\u307e\u3059\u3002\n<\/p>\n

\n\u9aa8\u9ac4\u7834\u58ca\u7684\u524d\u51e6\u7f6e\u3068\u6e1b\u91cf\u5f37\u5ea6\u524d\u51e6\u7f6e\uff08\u3044\u308f\u3086\u308b\u30df\u30cb\u79fb\u690d\uff09<\/strong>
\n\u3000\u79fb\u690d\u524d\u51e6\u7f6e\u306b\u306f\u5f93\u6765\u304b\u3089\u7528\u3044\u3089\u308c\u3066\u3044\u308b\u5168\u8eab\u653e\u5c04\u7dda\u7167\u5c04(TBI) 12Gy+\u5927\u91cf\u30b7\u30af\u30ed\u30d5\u30a9\u30b9\u30d5\u30a1\u30df\u30c9(CY)\u3001\u3082\u3057\u304f\u306f\u30d6\u30b9\u30eb\u30d5\u30a1\u30f3\uff08BU\uff09+ CY\u306a\u3069\u306e\u9aa8\u9ac4\u7834\u58ca\u7684\u524d\u51e6\u7f6e\uff08\u3044\u308f\u3086\u308b\u30d5\u30eb\u79fb\u690d\uff09\u3068\u30012000\u5e74\u524d\u5f8c\u304b\u3089\u958b\u767a\u304c\u9032\u3093\u3060\u30d5\u30eb\u30c0\u30e9\u30d3\u30f3\u306b\u30a2\u30eb\u30ad\u30eb\u5316\u5264\uff08CY, BU, MEL\uff09\u3092\u7d44\u307f\u5408\u308f\u305b\u308b\u6e1b\u91cf\u5f37\u5ea6\u524d\u51e6\u7f6e\uff08Reduced-intensity conditioning, \u3044\u308f\u3086\u308b\u30df\u30cb\u79fb\u690d\uff09\u304c\u3042\u308a\u307e\u3059\u3002\u30d5\u30eb\u79fb\u690d\u306e\u9069\u5fdc\u5e74\u9f62\u306f50 (\uff0d55)\u6b73\u304c\u4e00\u822c\u7684\u306a\u4e0a\u9650\u3067\u3059\u304c\u3001\u30df\u30cb\u79fb\u690d\u306f65\u6b73\u524d\u5f8c\uff08\u65bd\u8a2d\u306b\u3088\u308a\u7570\u306a\u308b\uff09\u307e\u3067\u9069\u5fdc\u3055\u308c\u308b\u3053\u3068\u304c\u591a\u304f\u306a\u3063\u3066\u3044\u307e\u3059\u3002\n<\/p>\n

\nGVHD\u4e88\u9632\u30fb\u6cbb\u7642<\/strong>
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\n\u611f\u67d3\u75c7\u4e88\u9632\u30fb\u6cbb\u7642<\/strong>
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